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Flupentixol + Melitracen
0.5 mg+10 mg
ACI Limited

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Indications

Flupentixol & Melitracen combination is indicated in-
  • Psychogenic depression
  • Depressive neurosis
  • Psychosomatic affections accompanied by anxiety and apathy
  • Menopausal depression
  • Depression in alcoholics and drug-addicts.

Therapeutic Class

Combined anxiolytics & anti-depressant drugs

Pharmacology

Maximum serum concentration is reached in about 4 hours after oral administration of Flupentixol and Melitracen. The half-life of Flupentixol is about 35 hours and that of Melitracen is about 19 hours. The combination of Flupentixol and Melitracen does not seem to influence the pharmacokinetic properties of the individual compounds.

Flupenthixol
 primarily acts as a neuroleptic drug. The antipsychotic effect of Flupenthixol is achieved by mixed blockade of dopamine D1 and D2 receptors. In the mesolimbic dopamine system of the brain, this accounts for the antipsychotic action of this drug. Flupenthixol has other effects on CNS. In the chemoreceptor trigger zone, the dopamine blockade accounts for the antiemetic effect of the drug.

Melitracen is a tricyclic antidepressant. It blocks the neuronal re-uptake of both serotonin and nor-epinephrine in the central nervous system, there by minimizing the

Side Effects

In the recommended doses, side effects are rare. These could be transient restlessness and insomnia.

Pregnancy & Lactation

The safety of this drug has not been established in pregnancy and lactation.

Precautions & Warnings

If previously the patient has been treated with tranquilizers with sedative effect these should be withdrawn gradually.